Brigham And Women's Hospital
EDUCATIONAL TITLES
Professor, Neurology, Harvard Medical School Director, Center For Neuro-Oncology, Dana-Farber Cancer
Institute
DF/HCC PROGRAM AFFILIATION
Neuro-Oncology, Member
Research Abstract
My research is directed towards the deveiopment of new therapies for brain tumors and leptomeningeal
metastases using gene therapy, inhibitors of angiogenesis, hormonal therapy and radionuclides. I am also
interested in the neurologic complications in cancer patients.
Publications
Nayak L, DeAngelis LM, Brandes AA, Peereboom DM, Galanis E, Lin NU, Soffietti R, Macdonald DR, Chamberlain
M,
Perry J, Jaeckle K, Mehta M, Stupp R, Muzikansky A, Pentsova E, Cloughesy T, Iwamoto FM, Tonn JC, Vogelbaum
MA, Wen PY, van den Bent MJ, Reardon DA. The Neurologic Assessment in Neuro-Oncology (NANO) scale: a tool to
assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria.
2017; 19:625-635. PubMed
Warren KE, Vezina G, Poussaint TY, Warmuth-Metz M, Chamberlain MC, Packer RJ, Brandes AA, Reiss M, Goldman
S,
Fisher MJ, Pollack IF, Prados MD, Wen PY, Chang SM, Dufour C, Zurakowski D, Kortmann RD, Kieran MW. Response
Assessment in Medulloblastoma and Leptomeningeal Seeding Tumors: Recommendations from the Response
Assessment
in Pediatric Neuro-Oncology Committee. 2017. PubMed
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan
DA,
Alexander BM, Aizer AA. Incidence and prognosis of patients with brain metastases at diagnosis of systemic
malignancy: A population-based study. 2017. PubMed
Wen PY, Jiang T, Schiff D. How can we develop therapies for glioblastoma more efficiently? Randomized versus
single-arm studies. 2017; 19:459-460. PubMed
Reardon DA, Wen PY, Wucherpfennig KW, Sampson JH. Immunomodulation for glioblastoma. Curr Opin Neurol 2017.
PubMed
Martin AM, Cagney DN, Catalano PJ, Warren LE, Bellon JR, Punglia RS, Claus EB, Lee EQ, Wen PY, Haas-Kogan
DA,
Alexander BM, Lin NU, Aizer AA. Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study.
JAMA Oncol 2017. PubMed
van den Bent MJ, Weller M, Wen PY, Kros JM, Aldape K, Chang S. A clinical perspective on the 2016 WHO brain
tumor classification and routine molecular diagnostics. 2017. PubMed
Tanguturi SK, Trippa L, Ramkissoon SH, Pelton K, Knoff D, Sandak D, Lindeman NI, Ligon AH, Beroukhim R,
Parmigiani G, Wen PY, Ligon KL, Alexander BM. Leveraging molecular datasets for biomarker-based clinical
trial
design in glioblastoma. 2017. PubMed
McFaline-Figueroa JR, Wen PY. The Viral Connection to Glioblastoma. Curr Infect Dis Rep 2017; 19:5.
PubMed
Nayak L, de Groot J, Wefel JS, Cloughesy TF, Lieberman F, Chang SM, Omuro A, Drappatz J, Batchelor TT,
DeAngelis LM, Gilbert MR, Aldape KD, Yung AW, Fisher J, Ye X, Chen A, Grossman S, Prados M, Wen PY. Phase I
trial of aflibercept (VEGF trap) with radiation therapy and concomitant and adjuvant temozolomide in
patients
with high-grade gliomas. J. Neurooncol. 2017. PubMed
Ellingson BM, Wen PY, Cloughesy TF. Modified Criteria for Radiographic Response Assessment in Glioblastoma
Clinical Trials. 2017. PubMed